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(Mouse) Smad1 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession P70340
Additional Information
Gene ID 17125
Other Names Mothers against decapentaplegic homolog 1, MAD homolog 1, Mothers against DPP homolog 1, Dwarfin-A, Dwf-A, Mothers-against-DPP-related 1, Mad-related protein 1, mMad1, SMAD family member 1, SMAD 1, Smad1, Smad1, Madh1, Madr1
Target/Specificity The synthetic peptide sequence is selected from aa 154-167 of HUMAN Smad1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Smad1
Synonyms Madh1, Madr1
Function Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q15797}. Nucleus {ECO:0000250|UniProtKB:Q15797}. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4. Colocalizes with LEMD3 at the nucleus inner membrane {ECO:0000250|UniProtKB:Q15797}
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Background

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene [removed]PubMed:15329343).

References

Yingling J.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:8940-8944(1996).
Zhao G.-Q.,et al.Mech. Dev. 61:63-73(1997).
Huang S.,et al.Gene 258:43-53(2000).
Carninci P.,et al.Science 309:1559-1563(2005).
Miura S.,et al.Mol. Cell. Biol. 20:9346-9355(2000).

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Cat# BP21203c
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