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(Mouse) Dpf2 Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q61103
Additional Information
Gene ID 19708
Other Names Zinc finger protein ubi-d4, Apoptosis response zinc finger protein, BRG1-associated factor 45D, BAF45D, D4, zinc and double PHD fingers family 2, Protein requiem, Dpf2, Baf45d, Req, Ubid4
Target/Specificity The synthetic peptide sequence is selected from aa 99-113 of HUMAN Dpf2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Dpf2
Synonyms Baf45d, Req, Ubid4
Function Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (By similarity). Might also have a role in the development and maturation of lymphoid cells (PubMed:7961935). Involved in the regulation of non-canonical NF- kappa-B pathway (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q92785}. Cytoplasm {ECO:0000250|UniProtKB:Q92785}
Tissue Location In embryo, highest levels are seen in brain, eyes, thymus and olfactory epithelium in nose, whereas several other tissues, including the musculoskeletal system, show moderate expression. In adult, higher expression in testis, medium in thymus and spleen, lower in certain parts of the brain as the hippocampus. No expression in adult heart, lung, liver, duodenum and kidney
Research Areas
Citations (0)
citation

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Background

May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.

References

Mertsalov I.B.,et al.Mamm. Genome 11:72-74(2000).
Carninci P.,et al.Science 309:1559-1563(2005).
Gabig T.G.,et al.J. Biol. Chem. 269:29515-29519(1994).
Gabig T.G.,et al.Mamm. Genome 9:660-665(1998).
Lessard J.,et al.Neuron 55:201-215(2007).

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$ 277.78
Cat# BP21223a
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