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MAGI2 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q86UL8
Additional Information
Gene ID 9863
Other Names Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2, Atrophin-1-interacting protein 1, AIP-1, Atrophin-1-interacting protein A, Membrane-associated guanylate kinase inverted 2, MAGI-2, MAGI2, ACVRINP1, AIP1, KIAA0705
Target/Specificity The synthetic peptide sequence is selected from aa 1123-1136 of HUMAN MAGI2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAGI2
Synonyms ACVRINP1, AIP1, KIAA0705
Function Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.
Cellular Location Cytoplasm. Late endosome. Cell junction, synapse, synaptosome Cell membrane; Peripheral membrane protein. Note=Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruted to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity).
Tissue Location Specifically expressed in brain.
Research Areas
Citations (0)

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Background

Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.

References

Wood J.D.,et al.Mol. Cell. Neurosci. 11:149-160(1998).
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
Wu X.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:4233-4238(2000).

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$ 80.00
$ 99.00
Cat# BP21243b
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