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PCGF6 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q9BYE7
Additional Information
Gene ID 84108
Other Names Polycomb group RING finger protein 6, Mel18 and Bmi1-like RING finger, RING finger protein 134, PCGF6, MBLR, RNF134
Target/Specificity The synthetic peptide sequence is selected from aa 215-229 of HUMAN PCGF6
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCGF6
Synonyms MBLR, RNF134
Function Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Cellular Location Nucleus
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Background

Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

References

Akasaka T.,et al.Genes Cells 7:835-850(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
Lee M.G.,et al.Cell 128:877-887(2007).
Maertens G.N.,et al.PLoS ONE 4:E6380-E6380(2009).

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$ 80.00
Cat# BP21285c
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