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(DANRE) aplnra Blocking Peptide (C-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q7SZP9
Additional Information
Gene ID 561935
Other Names Apelin receptor A, Angiotensin II receptor-like 1a, Angiotensin receptor-like 1a, G-protein coupled receptor APJ A, aplnra, agtrl1 {ECO:0000312|EMBL:ABI994701}, agtrl1a
Target/Specificity The synthetic peptide sequence is selected from aa 343-357 of HUMAN aplnra
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name aplnra
Synonyms agtrl1 {ECO:0000312|EMBL:ABI99470.1}, ag
Function Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively (PubMed:24316148, PubMed:24407481). Acts redundantly with agtrl1b in heart development.
Cellular Location Membrane; Multi-pass membrane protein
Tissue Location First expressed before epiboly in dorsal precursors. During epiboly, expressed in the enveloping layer, yolk syncytial layer and migrating mesendoderm. During segmentation stages, expressed in epithelial structures such as adaxial cells, border cells of the newly formed somites, developing lens, otic vesicles and venous vasculature
Research Areas
Citations (0)

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Background

Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively (PubMed:24316148, PubMed:24407481). Acts redundantly with agtrl1b in heart development.

References

Tucker B.,et al.Gene Expr. Patterns 7:258-265(2007).
Scott I.C.,et al.Dev. Cell 12:403-413(2007).
Chng S.C.,et al.Dev. Cell 27:672-680(2013).
Pauli A.,et al.Science 343:1248636-1248636(2014).

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$ 80.00
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Cat# BP21299b
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