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RABEP1 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15276 |
|---|
| Gene ID | 9135 |
|---|---|
| Other Names | Rab GTPase-binding effector protein 1, Rabaptin-4, Rabaptin-5, Rabaptin-5alpha, Renal carcinoma antigen NY-REN-17, RABEP1, RAB5EP, RABPT5, RABPT5A |
| Target/Specificity | The synthetic peptide sequence is selected from aa 427-441 of HUMAN RABEP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RABEP1 |
|---|---|
| Synonyms | RAB5EP, RABPT5, RABPT5A |
| Function | Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). |
| Cellular Location | Cytoplasm. Early endosome. Recycling endosome. Cytoplasmic vesicle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A.
References
Stenmark H.,et al.Cell 83:423-432(1995).
Nagelkerken B.,et al.Biochem. J. 346:593-601(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.
Horiuchi H.,et al.Cell 90:1149-1159(1997).
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