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(Mouse) Hopx Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q8R1H0
Additional Information
Gene ID 74318
Other Names Homeodomain-only protein, Homeobox-only protein, Odd homeobox protein 1, mOB1, Hopx, Hod, Hop, Ob1
Target/Specificity The synthetic peptide sequence is selected from aa 22-34 of HUMAN Hopx
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Hopx
Synonyms Hod, Hop, Ob1
Function Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy.
Cellular Location Nucleus. Cytoplasm. Note=According to PubMed:14516659 it is cytoplasmic
Tissue Location Expressed in the embryonic and adult heart and in the adult brain, liver, lung, skeletal muscle, intestine and spleen. Throughout embryonic and postnatal development, it is expressed in the myocardium.
Research Areas
Citations (0)

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Background

Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy.

References

Chen F.,et al.Cell 110:713-723(2002).
Shin C.H.,et al.Cell 110:725-735(2002).
Adu J.,et al.Mech. Dev. 119:S43-S47(2002).
Carninci P.,et al.Science 309:1559-1563(2005).
Kook H.,et al.J. Clin. Invest. 112:863-871(2003).

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$ 80.00
$ 99.00
Cat# BP21373c
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