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NFE4 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q86UQ8
Additional Information
Gene ID 58160
Other Names Transcription factor NF-E4, NFE4
Target/Specificity The synthetic peptide sequence is selected from aa 135-149 of HUMAN NFE4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NFE4
Function Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma- globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter.
Cellular Location Nucleus.
Tissue Location Specifically expressed in fetal liver, cord blood and bone marrow. Also expressed in the K562 and HEL cell lines, which constitutively express the fetal globin genes
Research Areas
Citations (0)

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Background

Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma- globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter.

References

Zhou W.,et al.Mol. Cell. Biol. 20:7662-7672(2000).
Hillier L.W.,et al.Nature 424:157-164(2003).
Zhao Q.,et al.Blood 107:2138-2145(2006).
Zhou W.,et al.J. Biol. Chem. 279:26227-26232(2004).
Zhao Q.,et al.J. Biol. Chem. 279:41477-41486(2004).

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$ 80.00
Cat# BP21375b
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