|Other Names||RING1 and YY1-binding protein, Death effector domain-associated factor, DED-associated factor, Rybp, Dedaf|
|Target/Specificity||The synthetic peptide sequence is selected from aa 131-145 of HUMAN Rybp|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Nucleus, nucleoplasm. Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies|
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Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis (By similarity).
Carninci P.,et al.Science 309:1559-1563(2005).
Garcia E.,et al.EMBO J. 18:3404-3418(1999).
Danen-van Oorschot A.A.M.M.,et al.Cell Death Differ. 11:564-573(2004).
Pirity M.K.,et al.Mol. Cell. Biol. 25:7193-7202(2005).
Arrigoni R.,et al.FEBS Lett. 580:6233-6241(2006).
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