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ACOT8 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession O14734
Additional Information
Gene ID 10005
Other Names Acyl-coenzyme A thioesterase 8, Acyl-CoA thioesterase 8, Choloyl-coenzyme A thioesterase, HIV-Nef-associated acyl-CoA thioesterase, PTE-2, Peroxisomal acyl-coenzyme A thioester hydrolase 1, PTE-1, Peroxisomal long-chain acyl-CoA thioesterase 1, Thioesterase II, hACTE-III, hACTEIII, hTE, ACOT8, ACTEIII, PTE1, PTE2
Target/Specificity The synthetic peptide sequence is selected from aa 275-290 of HUMAN ACOT8
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACOT8
Synonyms ACTEIII, PTE1, PTE2
Function Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:9299485, PubMed:9153233, PubMed:15194431). Competes with bile acid CoA:amino acid N-acyltransferase (BAAT) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (C2 to C20) (PubMed:9299485, PubMed:9153233). Inactive towards substrates with more than C20 aliphatic chains (PubMed:9153233). Involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431).
Cellular Location Cytoplasm. Peroxisome matrix. Note=Predominantly localized in the peroxisome (PubMed:10092594, PubMed:15194431)
Tissue Location Detected in a T-cell line (at protein level). Ubiquitous (PubMed:9153233, PubMed:9299485)
Research Areas
Citations (0)

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Background

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N- acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation.

References

Watanabe H.,et al.Biochem. Biophys. Res. Commun. 238:234-239(1997).
Liu L.X.,et al.J. Biol. Chem. 272:13779-13785(1997).
Jones J.M.,et al.J. Biol. Chem. 274:9216-9223(1999).
Deloukas P.,et al.Nature 414:865-871(2001).
Ishizuka M.,et al.Exp. Cell Res. 297:127-141(2004).

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$ 80.00
Cat# BP21424b
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