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NOTCH4 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q99466
Additional Information
Gene ID 4855
Other Names Neurogenic locus notch homolog protein 4, Notch 4, hNotch4, Notch 4 extracellular truncation, Notch 4 intracellular domain, NOTCH4, INT3
Target/Specificity The synthetic peptide sequence is selected from aa 1819-1831 of HUMAN NOTCH4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NOTCH4
Synonyms INT3
Function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes
Research Areas
Citations (0)

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Background

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).

References

Sugaya K.,et al.Gene 189:235-244(1997).
Li L.,et al.Genomics 51:45-58(1998).
Mungall A.J.,et al.Nature 425:805-811(2003).
Miyagawa T.,et al.Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
Gray G.E.,et al.Am. J. Pathol. 154:785-794(1999).

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$ 80.00
$ 99.00
Cat# BP21426b
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