NOTCH4 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q99466 |
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Gene ID | 4855 |
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Other Names | Neurogenic locus notch homolog protein 4, Notch 4, hNotch4, Notch 4 extracellular truncation, Notch 4 intracellular domain, NOTCH4, INT3 |
Target/Specificity | The synthetic peptide sequence is selected from aa 1819-1831 of HUMAN NOTCH4 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NOTCH4 (HGNC:7884) |
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Synonyms | INT3 |
Function | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity). |
Cellular Location | Cell membrane; Single-pass type I membrane protein |
Tissue Location | Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes |
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Background
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).
References
Sugaya K.,et al.Gene 189:235-244(1997).
Li L.,et al.Genomics 51:45-58(1998).
Mungall A.J.,et al.Nature 425:805-811(2003).
Miyagawa T.,et al.Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
Gray G.E.,et al.Am. J. Pathol. 154:785-794(1999).
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