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(Mouse) Bmi1 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession P25916
Additional Information
Gene ID 12151
Other Names Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, Bmi1, Bmi-1, Pcgf4
Target/Specificity The synthetic peptide sequence is selected from aa 235-248 of HUMAN Bmi1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Bmi1
Synonyms Bmi-1, Pcgf4
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).
Cellular Location Nucleus. Cytoplasm.
Tissue Location Detected in most organs with high expression levels in thymus, heart, brain and testis
Research Areas
Citations (0)

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Background

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).

References

Haupt Y.,et al.Cell 65:753-763(1991).
van Lohuiizen M.,et al.Cell 65:737-752(1991).
Cao R.,et al.Mol. Cell 20:845-854(2005).
Buchwald G.,et al.EMBO J. 25:2465-2474(2006).

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$ 80.00
$ 99.00
Cat# BP21436b
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