|Other Names||Rab11 family-interacting protein 5, Rab11-FIP5, Gamma-SNAP-associated factor 1, Gaf-1, Phosphoprotein pp75, Rab11-interacting protein Rip11, RAB11FIP5, GAF1, KIAA0857, RIP11|
|Target/Specificity||The synthetic peptide sequence is selected from aa 341-355 of HUMAN RAB11FIP5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GAF1, KIAA0857, RIP11|
|Function||Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.|
|Cellular Location||Cytoplasm. Recycling endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein Mitochondrion membrane; Peripheral membrane protein|
|Tissue Location||Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas.|
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Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.
Prekeris R.,et al.Mol. Cell 6:1437-1448(2000).
Nagase T.,et al.DNA Res. 5:355-364(1998).
Wang D.,et al.J. Clin. Invest. 104:1265-1275(1999).
Chen D.,et al.J. Biol. Chem. 276:13127-13135(2001).
Wallace D.M.,et al.Biochem. Biophys. Res. Commun. 299:770-779(2002).
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