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PRPF8 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q6P2Q9
Additional Information
Gene ID 10594
Other Names Pre-mRNA-processing-splicing factor 8, 220 kDa U5 snRNP-specific protein, PRP8 homolog, Splicing factor Prp8, p220, PRPF8, PRPC8
Target/Specificity The synthetic peptide sequence is selected from aa 2239-2253 of HUMAN PRPF8
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRPF8
Synonyms PRPC8
Function Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
Cellular Location Nucleus speckle.
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.

References

Luo H.R.,et al.RNA 5:893-908(1999).
Shimada Y.,et al.Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (DEC-2008) to UniProtKB.
Anderson G.J.,et al.Nature 342:819-821(1989).
Bach M.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:6038-6042(1989).

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$ 80.00
Cat# BP21455b
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