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AQPEP Blocking Peptide (C-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q6Q4G3
Additional Information
Gene ID 206338
Other Names Aminopeptidase Q, AP-Q, 3411-, CHL2 antigen, Laeverin, AQPEP, LVRN
Target/Specificity The synthetic peptide sequence is selected from aa 844-857 of HUMAN AQPEP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AQPEP
Synonyms LVRN
Function Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo- maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met- MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C.
Cellular Location Membrane; Single-pass type II membrane protein
Tissue Location Specifically expressed in placenta and not in other tissues. Mainly found at the cell surface region of the extravillous trophoblasts. Detected on extravillous trophoblasts in the outer layer of the chorion laeve in the fetal membrane Not detected on either fetal amnionic epithelial cells or maternal decidual cells. Also detected in the migrating extravillous trophoblasts in the maternal decidual tissues (at protein level)
Research Areas
Citations (0)

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Background

Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo- maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met- MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C.

References

Fujiwara H.,et al.Biochem. Biophys. Res. Commun. 313:962-968(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Maruyama M.,et al.J. Biol. Chem. 282:20088-20096(2007).

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$ 80.00
$ 99.00
Cat# BP21461b
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