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WNT2 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession P09544
Additional Information
Gene ID 7472
Other Names Protein Wnt-2, Int-1-like protein 1, Int-1-related protein, IRP, WNT2, INT1L1, IRP
Target/Specificity The synthetic peptide sequence is selected from aa 254-267 of HUMAN WNT2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name WNT2
Synonyms INT1L1, IRP
Function Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20018874). Functions as a upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
Cellular Location Secreted, extracellular space, extracellular matrix. Secreted
Tissue Location Expressed in brain in the thalamus, in fetal and adult lung and in placenta.
Research Areas
Citations (0)
citation

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Background

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

References

Wainwright B.J.,et al.EMBO J. 7:1743-1748(1988).
Farrall M.,et al.Submitted (APR-1988) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 424:157-164(2003).

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$ 277.78
Cat# BP21468c
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