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SRY Blocking Peptide (N-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q05066
Additional Information
Gene ID 6736
Other Names Sex-determining region Y protein, Testis-determining factor, SRY, TDF
Target/Specificity The synthetic peptide sequence is selected from aa 52-62 of HUMAN SRY
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SRY
Synonyms TDF
Function Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.
Cellular Location Nucleus speckle. Cytoplasm. Note=Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity).
Research Areas
Citations (0)

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Background

Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.

References

Sinclair A.H.,et al.Nature 346:240-244(1990).
Su H.,et al.Am. J. Hum. Genet. 52:24-38(1993).
Behlke M.A.,et al.Genomics 17:736-739(1993).
Whitfield L.S.,et al.Genomics 27:306-311(1995).
Ferrari S.,et al.EMBO J. 11:4497-4506(1992).

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$ 80.00
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Cat# BP21504a
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