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Mouse Dnmt3b Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession O88509
Additional Information
Gene ID 13436
Other Names DNA (cytosine-5)-methyltransferase 3B, Dnmt3b, DNA methyltransferase MmuIIIB, DNA MTase MmuIIIB, MMmuIIIB, Dnmt3b
Target/Specificity The synthetic peptide sequence is selected from aa 356-370 of HUMAN Dnmt3b
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Dnmt3b
Function Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co- repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Function as transcriptional corepressor by associating with ZHX1 (By similarity).
Cellular Location Nucleus. Note=Accumulates in the major satellite repeats at pericentric heterochromatin
Research Areas
Citations (0)

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Background

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co- repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Function as transcriptional corepressor by associating with ZHX1 (By similarity).

References

Okano M.,et al.Nat. Genet. 19:219-220(1998).
Yin B.,et al.Zhongguo Yi Xue Ke Xue Yuan Xue Bao 21:431-438(1999).
Okano M.,et al.Cell 99:247-257(1999).
Gowher H.,et al.J. Biol. Chem. 277:20409-20414(2002).
Christophorou M.A.,et al.Nature 507:104-108(2014).

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$ 80.00
$ 99.00
Cat# BP21512c
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