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CASP14 Blocking Peptide (N-Term)

Synthetic peptide

Product Information
Primary Accession P31944
Additional Information
Gene ID 23581
Other Names Caspase-14, CASP-14, 3422-, Caspase-14 subunit p19, Caspase-14 subunit p10, CASP14
Target/Specificity The synthetic peptide sequence is selected from aa 59-73 of HUMAN CASP14
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP14
Function Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).
Cellular Location Cytoplasm. Nucleus
Tissue Location Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels (PubMed:11175259). The p17/10 mature form is expressed in epidermis stratum corneum, the p20/p8 intermediate form in epidermis upper granular cells of the stratum granulosum (PubMed:22825846).
Research Areas
Citations (0)

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Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity).


Eckhart L.,et al.Biochem. Biophys. Res. Commun. 277:655-659(2000).
Pistritto G.,et al.Cell Death Differ. 9:995-1006(2002).
Rasmussen H.H.,et al.Electrophoresis 13:960-969(1992).
Lippens S.,et al.Cell Death Differ. 7:1218-1224(2000).
Chien A.J.,et al.Biochem. Biophys. Res. Commun. 296:911-917(2002).

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$ 80.00
$ 99.00
Cat# BP21517a
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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