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PFN1 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession P07737
Additional Information
Gene ID 5216
Other Names Profilin-1, Epididymis tissue protein Li 184a, Profilin I, PFN1
Target/Specificity The synthetic peptide sequence is selected from aa 87-100 of HUMAN PFN1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PFN1
Function Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Cellular Location Cytoplasm, cytoskeleton.
Tissue Location Expressed in epididymis (at protein level).
Research Areas
Citations (0)

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Background

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.

References

Kwiatkowski D.J.,et al.J. Biol. Chem. 263:5910-5915(1988).
Li J.,et al.Mol. Cell. Proteomics 9:2517-2528(2010).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.

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$ 80.00
Cat# BP21569b
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