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Mouse Klf4 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q60793
Additional Information
Gene ID 16600
Other Names Krueppel-like factor 4, Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor, Klf4, Ezf, Gklf, Zie
Target/Specificity The synthetic peptide sequence is selected from aa 378-390 of HUMAN Klf4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Klf4
Synonyms Ezf, Gklf, Zie
Function Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity).
Cellular Location Nucleus.
Tissue Location Highest expression in the colon. Lower levels in testis, lung and small intestine
Research Areas
Citations (0)

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Background

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity).

References

Shields J.M.,et al.J. Biol. Chem. 271:20009-20017(1996).
Garrett-Sinha L.A.,et al.J. Biol. Chem. 271:31384-31390(1996).
Mahatan C.S.,et al.Nucleic Acids Res. 27:4562-4569(1999).
Chen Z.-Y.,et al.Exp. Cell Res. 281:19-27(2002).
Carninci P.,et al.Science 309:1559-1563(2005).

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$ 80.00
Cat# BP21583b
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