GZMH Blocking Peptide (N-Term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P20718 |
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Gene ID | 2999 |
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Other Names | Granzyme H, 3421-, CCP-X, Cathepsin G-like 2, CTSGL2, Cytotoxic T-lymphocyte proteinase, Cytotoxic serine protease C, CSP-C, GZMH, CGL2, CTSGL2 |
Target/Specificity | The synthetic peptide sequence is selected from aa 19-32 of HUMAN GZMH |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GZMH |
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Synonyms | CGL2, CTSGL2 |
Function | Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. |
Cellular Location | Cytolytic granule. |
Tissue Location | Constitutively expressed in NK cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.
References
Meier M.,et al.Biochemistry 29:4042-4049(1990).
Haddad P.,et al.Int. Immunol. 3:57-66(1991).
Klein J.L.,et al.Tissue Antigens 35:220-228(1990).
Kothapalli R.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Heilig R.,et al.Nature 421:601-607(2003).
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