Mouse Srms Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q62270 |
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Other Names | Tyrosine-protein kinase Srms, PTK70, Srms, Srm |
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Target/Specificity | The synthetic peptide sequence is selected from aa 113-127 of HUMAN Srms |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Srms |
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Synonyms | Srm |
Function | Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent. Phosphorylates OTUB1, promoting deubiquitination of RPTOR. |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9H3Y6}. Note=Localizes to punctate cytoplasmic structures {ECO:0000250|UniProtKB:Q9H3Y6} |
Tissue Location | Higher expression in liver, lung, thymus and skin than in brain, kidney, heart and spleen (PubMed:9226137). In skin, highly expressed in keratinocytes (PubMed:9226137). Abundant in lung, liver, spleen, kidney and testis and is also detected in the cerebrum (PubMed:7935409). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin.
References
Kawachi Y.,et al.Exp. Dermatol. 6:140-146(1997).
Kohmura N.,et al.Mol. Cell. Biol. 14:6915-6925(1994).
Wall M.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
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