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DSTYK Blocking Peptide (N-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q6XUX3
Additional Information
Gene ID 25778
Other Names Dual serine/threonine and tyrosine protein kinase, Dusty protein kinase, Dusty PK, RIP-homologous kinase, Receptor-interacting serine/threonine-protein kinase 5, Sugen kinase 496, SgK496, DSTYK, KIAA0472, RIP5, RIPK5, SGK496
Target/Specificity The synthetic peptide sequence is selected from aa 256-270 of HUMAN DSTYK
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DSTYK
Synonyms KIAA0472, RIP5, RIPK5, SGK496
Function Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death.
Cellular Location Cytoplasm. Cell membrane {ECO:0000250|UniProtKB:Q6XUX1}. Apical cell membrane. Basolateral cell membrane. Cell junction {ECO:0000250|UniProtKB:Q6XUX1}. Note=Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane (By similarity). Detected in basolateral and apical membranes of all tubular epithelia. {ECO:0000250|UniProtKB:Q6XUX1, ECO:0000269|PubMed:23862974}
Tissue Location Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines
Research Areas
Citations (0)

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Background

Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death.

References

Peng J.,et al.Biochim. Biophys. Acta 1759:562-572(2006).
Zhao Z.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Seki N.,et al.DNA Res. 4:345-349(1997).
Zha J.,et al.Biochem. Biophys. Res. Commun. 319:298-303(2004).

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$ 80.00
Cat# BP21613a
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