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Mouse Lmtk3 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q5XJV6
Additional Information
Gene ID 381983
Other Names Serine/threonine-protein kinase LMTK3, Apoptosis-associated tyrosine kinase 3, Lemur tyrosine kinase 3, Lmtk3, Aatyk3
Target/Specificity The synthetic peptide sequence is selected from aa 891-905 of HUMAN Lmtk3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Lmtk3
Synonyms Aatyk3
Function Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (By similarity). Involved in endocytic trafficking of N-methyl-D- aspartate receptors (NMDAR) in neurons (PubMed:24760852).
Cellular Location Membrane; Single-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Golgi apparatus membrane. Note=Punctate pattern in cell projections
Tissue Location Expressed in brain. Predominantly expressed in cerebral cortex, thalamus, the cerebellum and hippocampal formation (at protein level).
Research Areas
Citations (0)

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References

Tomomura M.,et al.Neuroscience 148:510-521(2007).
Trinidad J.C.,et al.Mol. Cell. Proteomics 5:914-922(2006).
Munton R.P.,et al.Mol. Cell. Proteomics 6:283-293(2007).

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$ 80.00
Cat# BP21694c
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