|Other Names||Serine/threonine-protein kinase LMTK3, Apoptosis-associated tyrosine kinase 3, Lemur tyrosine kinase 3, Lmtk3, Aatyk3|
|Target/Specificity||The synthetic peptide sequence is selected from aa 891-905 of HUMAN Lmtk3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (By similarity). Involved in endocytic trafficking of N-methyl-D- aspartate receptors (NMDAR) in neurons (PubMed:24760852).|
|Cellular Location||Membrane; Single-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Golgi apparatus membrane. Note=Punctate pattern in cell projections|
|Tissue Location||Expressed in brain. Predominantly expressed in cerebral cortex, thalamus, the cerebellum and hippocampal formation (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Tomomura M.,et al.Neuroscience 148:510-521(2007).
Trinidad J.C.,et al.Mol. Cell. Proteomics 5:914-922(2006).
Munton R.P.,et al.Mol. Cell. Proteomics 6:283-293(2007).
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