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UBE2M Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P61081
Other Accession NP_003960
Clone Names 3062004
Peptide ID 3062004
Additional Information
Gene ID 9040
Other Names NEDD8-conjugating enzyme Ubc12, 632-, NEDD8 carrier protein, NEDD8 protein ligase, Ubiquitin-conjugating enzyme E2 M, UBE2M, UBC12
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2169b was selected from the Center region of human UBE2M . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBE2M
Synonyms UBC12
Function Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
Research Areas
Citations (0)

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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2M is a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin.


Gong, L., et al., J. Biol. Chem. 274(17):12036-12042 (1999).Osaka, F., et al., Genes Dev. 12(15):2263-2268 (1998).

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$ 80.00
Cat# BP2169b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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