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CACNA1A Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession O00555
Additional Information
Gene ID 773
Other Names Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Brain calcium channel I, BI, Calcium channel, L type, alpha-1 polypeptide isoform 4, Voltage-gated calcium channel subunit alpha Cav21, CACNA1A, CACH4, CACN3, CACNL1A4
Target/Specificity The synthetic peptide sequence is selected from aa 918-932 of HUMAN CACNA1A
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CACNA1A
Synonyms CACH4, CACN3, CACNL1A4
Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Brain specific; mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P- type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells.
Research Areas
Citations (0)

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Background

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).

References

Hans M.,et al.Biophys. J. 76:1384-1400(1999).
Ophoff R.A.,et al.Cell 87:543-552(1996).
Zhuchenko O.,et al.Nat. Genet. 15:62-69(1997).
Toru S.,et al.J. Biol. Chem. 275:10893-10898(2000).
Grimwood J.,et al.Nature 428:529-535(2004).

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$ 80.00
Cat# BP21701c
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