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NACA2 Blocking Peptide (N-Term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H009 |
|---|
| Gene ID | 342538 |
|---|---|
| Other Names | Nascent polypeptide-associated complex subunit alpha-2, Alpha-NAC-like, Hom s 201, Nascent polypeptide-associated complex subunit alpha-like, NAC-alpha-like, NACA2, NACAL |
| Target/Specificity | The synthetic peptide sequence is selected from aa 56-69 of HUMAN NACA2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NACA2 |
|---|---|
| Synonyms | NACAL |
| Function | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). |
| Cellular Location | Cytoplasm. Nucleus. |
| Tissue Location | Expressed specifically in testis and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).
References
Mossabeb R.,et al.J. Invest. Dermatol. 119:820-829(2002).
Marques A.C.,et al.PLoS Biol. 3:E357-E357(2005).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
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