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PTGFR Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P43088 |
|---|
| Gene ID | 5737 |
|---|---|
| Other Names | Prostaglandin F2-alpha receptor, PGF receptor, PGF2-alpha receptor, Prostanoid FP receptor, PTGFR |
| Target/Specificity | The synthetic peptide sequence is selected from aa 189-199 of HUMAN PTGFR |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PTGFR |
|---|---|
| Function | Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Eye.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
References
Abramovitz M.,et al.J. Biol. Chem. 269:2632-2636(1994).
Kunapuli P.,et al.J. Biol. Chem. 272:27147-27154(1997).
Kopatz S.A.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Vielhauer G.A.,et al.Arch. Biochem. Biophys. 421:175-185(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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