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SAG Blocking Peptide (C-Term)

Synthetic peptide

     
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Product Information
Primary Accession P10523
Additional Information
Gene ID 6295
Other Names S-arrestin, 48 kDa protein, Retinal S-antigen, S-AG, Rod photoreceptor arrestin, SAG
Target/Specificity The synthetic peptide sequence is selected from aa 293-307 of HUMAN SAG
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SAG
Function Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G- proteins for the same binding site on RHO (By similarity). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (PubMed:9565049).
Cellular Location Cell projection, cilium, photoreceptor outer segment. Membrane {ECO:0000250|UniProtKB:P20443}; Peripheral membrane protein {ECO:0000250|UniProtKB:P20443}. Note=Highly expressed in photoreceptor outer segments in light-exposed retina. Evenly distributed throughout rod photoreceptor cells in dark-adapted retina (By similarity). Predominantly dectected at the proximal region of photoreceptor outer segments, near disk membranes (PubMed:3720866). {ECO:0000250|UniProtKB:P08168, ECO:0000269|PubMed:3720866}
Tissue Location Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level)
Research Areas
Citations (0)

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Background

Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated- phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase.

References

Yamaki K.,et al.FEBS Lett. 234:39-43(1988).
Yamaki K.,et al.FEBS Lett. 236:507-507(1988).
Yamamoto S.,et al.Nat. Genet. 15:175-178(1997).
Hillier L.W.,et al.Nature 434:724-731(2005).
Roni V.,et al.BMC Genomics 8:42-42(2007).

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$ 80.00
Cat# BP21724b
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