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RLBP1 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession P12271
Additional Information
Gene ID 6017
Other Names Retinaldehyde-binding protein 1, Cellular retinaldehyde-binding protein, RLBP1, CRALBP
Target/Specificity The synthetic peptide sequence is selected from aa 275-288 of HUMAN RLBP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RLBP1
Synonyms CRALBP
Function Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.
Cellular Location Cytoplasm.
Tissue Location Retina and pineal gland. Not present in photoreceptor cells but is expressed abundantly in the adjacent retinal pigment epithelium (RPE) and in the Mueller glial cells of the retina.
Research Areas
Citations (0)

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Background

Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.

References

Crabb J.W.,et al.J. Biol. Chem. 263:18688-18692(1988).
Intres R.,et al.J. Biol. Chem. 269:25411-25418(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Crabb J.W.,et al.Protein Sci. 7:746-757(1998).

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$ 80.00
Cat# BP21727b
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