DMRT2 Blocking Peptide (N-Term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y5R5 |
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Gene ID | 10655 |
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Other Names | Doublesex- and mab-3-related transcription factor 2, Doublesex-like 2 protein, DSXL-2, DMRT2, DSXL2 |
Target/Specificity | The synthetic peptide sequence is selected from aa 242-256 of HUMAN DMRT2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DMRT2 |
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Synonyms | DSXL2 |
Function | Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}. |
Tissue Location | Expressed in testis, kidney and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity).
References
Raymond C.S.,et al.Hum. Mol. Genet. 8:989-996(1999).
Ottolenghi C.,et al.Genomics 64:179-186(2000).
Calvari V.,et al.Genomics 65:203-212(2000).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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