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FAAP24 Blocking Peptide (N-Term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BTP7 |
|---|
| Gene ID | 91442 |
|---|---|
| Other Names | Fanconi anemia-associated protein of 24 kDa, FAAP24, C19orf40 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 1-12 of HUMAN FAAP24 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FAAP24 {ECO:0000303|PubMed:17289582, ECO:0000312|HGNC:HGNC:28467} |
|---|---|
| Function | Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ciccia A.,et al.Mol. Cell 25:331-343(2007).
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