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ATXN2 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q99700
Additional Information
Gene ID 6311
Other Names Ataxin-2, Spinocerebellar ataxia type 2 protein, Trinucleotide repeat-containing gene 13 protein, ATXN2, ATX2, SCA2, TNRC13
Target/Specificity The synthetic peptide sequence is selected from aa 745-757 of HUMAN ATXN2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATXN2
Synonyms ATX2, SCA2, TNRC13
Function Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.
Cellular Location Cytoplasm.
Tissue Location Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus
Research Areas
Citations (0)

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Background

Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.

References

Pulst S.-M.,et al.Nat. Genet. 14:269-276(1996).
Sanpei K.,et al.Nat. Genet. 14:277-284(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Imbert G.,et al.Nat. Genet. 14:285-291(1996).

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$ 80.00
Cat# BP21768c
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