Zebrafish wnt8a Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P51028 |
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Gene ID | 30122 |
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Other Names | Protein Wnt-8a, wnt8a, wnt-8, wnt8 |
Target/Specificity | The synthetic peptide sequence is selected from aa 155-170 of HUMAN wnt8a |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | wnt8a |
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Synonyms | wnt-8, wnt8 |
Function | Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Required for mesoderm and neural ectoderm patterning during gastrulation (PubMed:11703928). Involved in axis formation during embryonic development, via activation of canonical Wnt/CTNNB1 signaling (PubMed:11703928, PubMed:25371059). May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis (PubMed:7600994). |
Cellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q9H1J5}. Secreted {ECO:0000250|UniProtKB:Q9H1J5} |
Tissue Location | Expressed in the margin of the pregastrula embryo destined to be the future mesoderm. |
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Background
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Is likely to signal over only few cell diameters. May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis.
References
Kelly G.M.,et al.Development 121:1787-1799(1995).
Lekven A.C.,et al.Dev. Cell 1:103-114(2001).
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