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TRIM55 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BYV6 |
|---|
| Gene ID | 84675 |
|---|---|
| Other Names | Tripartite motif-containing protein 55, Muscle-specific RING finger protein 2, MuRF-2, MuRF2, RING finger protein 29, TRIM55, MURF2, RNF29 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 315-329 of HUMAN TRIM55 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TRIM55 |
|---|---|
| Synonyms | MURF2, RNF29 |
| Function | E3 ubiquitin ligase that plays an important role in regulating cardiac development and contractility, muscle growth, metabolism, and fiber-type differentiation. Acts as a critical factor that regulates cardiomyocyte size during development in concert with TRIM63 by regulating E2F1-mediated gene expression (By similarity). Plays a role in apoptosis induction in cardiomyocytes by promoting ubiquitination of the DUSP1 phosphatase. Promotes non-canonical NF- kappa-B signaling and B-cell-mediated immune responses by mediating NFKB2 'Lys-48'-linked ubiquitination and processing. In turn, NFKB2 is further processed by valosin-containing protein/VCP, an ATPase that mediates ubiquitin-dependent protein degradation by the proteasome. May play a role in preventing macrophages from producing inflammatory factors and migrating by downregulating the level of nuclear NF-kappa-B subunit RELA. Modifies also PPARG via polyubiquitination and accelerates PPARG proteasomal degradation to inhibit its activity (PubMed:36737649). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:G3X8Y1}. Cytoplasm {ECO:0000250|UniProtKB:G3X8Y1}. Note=TLR4 signaling pathway promotes nuclear translocation. {ECO:0000250|UniProtKB:G3X8Y1} |
| Tissue Location | Highly expressed in muscle. Low-level expression in liver. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May regulate gene expression and protein turnover in muscle cells.
References
Centner T.,et al.J. Mol. Biol. 306:717-726(2001).
Pizon V.,et al.J. Cell Sci. 115:4469-4482(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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