|Other Names||Myc-associated zinc finger protein, MAZI, Pur-1, Purine-binding transcription factor, Serum amyloid A-activating factor-1, SAF-1, Transcription factor Zif87, ZF87, Zinc finger protein 801, MAZ, ZNF801|
|Target/Specificity||The synthetic peptide sequence is selected from aa 315-327 of HUMAN MAZ|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.|
|Cellular Location||Nucleus. Note=In brains of Alzheimer disease patients, present in a plaque- like structures|
|Tissue Location||Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).|
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May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.
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Pyrc J.J.,et al.Biochemistry 31:4102-4110(1992).
Tsutsui H.,et al.Biochem. Biophys. Res. Commun. 226:801-809(1996).
Parks C.L.,et al.J. Biol. Chem. 271:4417-4430(1996).
Song J.,et al.J. Biol. Chem. 273:20603-20614(1998).
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