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CYR61 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession O00622
Additional Information
Gene ID 3491
Other Names Protein CYR61, CCN family member 1, Cysteine-rich angiogenic inducer 61, Insulin-like growth factor-binding protein 10, IBP-10, IGF-binding protein 10, IGFBP-10, Protein GIG1, CYR61, CCN1, GIG1, IGFBP10
Target/Specificity The synthetic peptide sequence is selected from aa 163-174 of HUMAN CYR61
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCN1 (HGNC:2654)
Function Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Cellular Location Secreted.
Research Areas
Citations (0)
citation

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Background

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

References

Jay P.,et al.Oncogene 14:1753-1757(1997).
Martinerie C.,et al.Mol. Pathol. 50:310-316(1997).
Albrecht C.,et al.J. Biol. Chem. 275:28929-28936(2000).
Kolesnikova T.V.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Bi A.B.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.

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$ 277.78
Cat# BP21805c
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