|Other Names||Cytosolic phospholipase A2 delta, cPLA2-delta, Phospholipase A2 group IVD, PLA2G4D|
|Target/Specificity||The synthetic peptide sequence is selected from aa 774-786 of HUMAN PLA2G4D|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.|
|Cellular Location||Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocates to membrane vesicles in a calcium-dependent fashion. Translocates to perinuclear regions upon ionomycin stimulation (By similarity)|
|Tissue Location||Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin.|
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Provided below are standard protocols that you may find useful for product applications.
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.
Chiba H.,et al.J. Biol. Chem. 279:12890-12897(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Tao R.,et al.Prostaglandins Leukot. Essent. Fatty Acids 73:419-422(2005).
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