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OPHN1 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession O60890
Additional Information
Gene ID 4983
Other Names Oligophrenin-1, OPHN1
Target/Specificity The synthetic peptide sequence is selected from aa 304-315 of HUMAN OPHN1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name OPHN1
Function Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity).
Cellular Location Cell junction, synapse. Cell projection, axon. Cell projection, dendritic spine. Cell projection, dendrite. Cytoplasm. Note=Present in both presynaptic and postsynaptic sites.
Tissue Location Expressed in brain.
Research Areas
Citations (0)

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Background

Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity).

References

Billuart P.,et al.Nature 392:923-926(1998).
Tentler D.,et al.Eur. J. Hum. Genet. 7:541-548(1999).
Billuart P.,et al.Ann. Genet. 43:5-9(2000).
Kitano T.,et al.Mol. Biol. Evol. 20:1281-1289(2003).
Ross M.T.,et al.Nature 434:325-337(2005).

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$ 80.00
Cat# BP21819c
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