|Other Names||Anoctamin-10, Transmembrane protein 16K, ANO10, TMEM16K|
|Target/Specificity||The synthetic peptide sequence is selected from aa 640-653 of HUMAN ANO10|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.|
|Cellular Location||Cell membrane; Multi- pass membrane protein Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane|
|Tissue Location||Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain.|
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Provided below are standard protocols that you may find useful for product applications.
Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Schreiber R.,et al.J. Biol. Chem. 285:7838-7845(2010).
Duran C.,et al.Acta Pharmacol. Sin. 32:685-692(2011).
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