|Other Names||Adenomatous polyposis coli protein 2, Adenomatous polyposis coli protein-like, APC-like, APC2, APCL|
|Target/Specificity||The synthetic peptide sequence is selected from aa 142-152 of HUMAN APC2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329).|
|Cellular Location||Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasm. Cytoplasm, perinuclear region. Note=Associated with actin filaments (PubMed:11691822, PubMed:25753423). Associated with microtubule network (PubMed:10644998, PubMed:11691822, PubMed:25753423).|
|Tissue Location||Widely expressed (at protein level). Specifically expressed in the CNS.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.
Nakagawa H.,et al.Cancer Res. 58:5176-5181(1998).
Nakagawa H.,et al.Jpn. J. Cancer Res. 90:982-986(1999).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Carr I.M.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
van Es J.H.,et al.Curr. Biol. 9:105-108(1999).
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