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GRIN2B Blocking Peptide (C-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q13224
Other Accession Q01097, Q00960
Additional Information
Gene ID 2904
Other Names Glutamate receptor ionotropic, NMDA 2B, GluN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B, N-methyl-D-aspartate receptor subunit 3, NR3, hNR3, GRIN2B, NMDAR2B
Target/Specificity The synthetic peptide sequence is selected from aa 1320-1332 of HUMAN GRIN2B
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRIN2B
Synonyms NMDAR2B
Function NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein
Tissue Location Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
Research Areas
Citations (0)

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Background

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).

References

Adams S.L.,et al.Biochim. Biophys. Acta 1260:105-108(1995).
Hess S.D.,et al.J. Pharmacol. Exp. Ther. 278:808-816(1996).
Mandich P.,et al.Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
Mandich P.,et al.Genomics 22:216-218(1994).
Schito A.M.,et al.Neurosci. Lett. 239:49-53(1997).

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$ 80.00
Cat# BP21859b
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