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TFDP1 Blocking Peptide (N-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q14186
Other Accession Q17QZ4, Q08639
Additional Information
Gene ID 7027
Other Names Transcription factor Dp-1, DRTF1-polypeptide 1, DRTF1, E2F dimerization partner 1, TFDP1, DP1
Target/Specificity The synthetic peptide sequence is selected from aa 103-114 of HUMAN TFDP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TFDP1
Synonyms DP1
Function Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Cellular Location Nucleus.
Tissue Location Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart
Research Areas
Citations (0)

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Background

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis.

References

Helin K.,et al.Genes Dev. 7:1850-1861(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bandara L.R.,et al.EMBO J. 13:3104-3114(1994).

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$ 80.00
Cat# BP21890a
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