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GPR124 Blocking Peptide (C-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q96PE1
Additional Information
Gene ID 25960
Other Names G-protein coupled receptor 124, Tumor endothelial marker 5, GPR124, KIAA1531, TEM5
Target/Specificity The synthetic peptide sequence is selected from aa 1279-1293 of HUMAN GPR124
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADGRA2 (HGNC:17849)
Function Endothelial receptor which functions as a WNT7-specific coactivator of canonical Wnt signaling (By similarity). Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity). Has a major role in establishing the blood-brain barrier (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628).
Cellular Location Cell membrane; Multi- pass membrane protein. Cell projection, filopodium. Note=Enriched at lateral cell borders and also at sites of cell-ECM (extracellular matrix) contact.
Tissue Location Expressed in endothelial cells (at protein level) (PubMed:15021905, PubMed:16982628). Abundantly expressed in heart, placenta, ovary, small intestine, and colon (PubMed:15021905).
Research Areas
Citations (0)

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Background

Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity).

References

Carson-Walter E.B.,et al.Cancer Res. 61:6649-6655(2001).
Nagase T.,et al.DNA Res. 7:143-150(2000).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).

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$ 80.00
Cat# BP21894b
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