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TNRC6A Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q8NDV7
Additional Information
Gene ID 27327
Other Names Trinucleotide repeat-containing gene 6A protein, CAG repeat protein 26, EMSY interactor protein, GW182 autoantigen, Protein GW1, Glycine-tryptophan protein of 182 kDa, TNRC6A, CAGH26, KIAA1460, TNRC6
Target/Specificity The synthetic peptide sequence is selected from aa 875-885 of HUMAN TNRC6A
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNRC6A
Synonyms CAGH26, KIAA1460, TNRC6
Function Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA- dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
Cellular Location Cytoplasm, P-body Note=Mammalian P-bodies are also known as GW bodies (GWBs)
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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Background

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA- dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.

References

Eystathioy T.,et al.Mol. Biol. Cell 13:1338-1351(2002).
Hughes-Davies L.,et al.Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Martin J.,et al.Nature 432:988-994(2004).
Margolis R.L.,et al.Hum. Genet. 100:114-122(1997).

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$ 80.00
Cat# BP21900c
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