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NT5M Blocking Peptide (C-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q9NPB1
Other Accession Q8VCE6
Additional Information
Gene ID 56953
Other Names 5'(3')-deoxyribonucleotidase, mitochondrial, 5', 3'-nucleotidase, mitochondrial, 3.1.3.-, Deoxy-5'-nucleotidase 2, dNT-2, NT5M, DNT2
Target/Specificity The synthetic peptide sequence is selected from aa 215-226 of HUMAN NT5M
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NT5M
Synonyms DNT2
Function Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Cellular Location Mitochondrion.
Tissue Location Highly expressed in heart, brain and skeletal muscle. Detected at very low levels in kidney and pancreas
Research Areas
Citations (0)

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Background

Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.

References

Rampazzo C.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:8239-8244(2000).
Rinaldo-Matthis A.,et al.Nat. Struct. Biol. 9:779-787(2002).

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$ 80.00
Cat# BP21968b
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