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CERS4 Blocking Peptide (N-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q9HA82
Additional Information
Other Names Ceramide synthase 4, CerS4, LAG1 longevity assurance homolog 4, CERS4, LASS4
Target/Specificity The synthetic peptide sequence is selected from aa 21-31 of HUMAN CERS4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CERS4
Synonyms LASS4
Function May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity).
Cellular Location Nucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein EMBL; AK022151; BAB13972.1; -; mRNA EMBL; AC022146; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471139; EAW68940.1; -; Genomic_DNA EMBL; CH471139; EAW68941.1; -; Genomic_DNA EMBL; CH471139; EAW68942.1; -; Genomic_DNA EMBL; CH471139; EAW68945.1; -; Genomic_DNA EMBL; BC009828; AAH09828.1; -; mRNA CCDS; CCDS12197.1; - RefSeq; NP_078828.2; NM_024552.2 RefSeq; XP_011526592.1; XM_011528290.2 RefSeq; XP_011526593.1; XM_011528291.2 RefSeq; XP_011526594.1; XM_011528292.2 RefSeq; XP_011526595.1; XM_011528293.2 RefSeq; XP_011526596.1; XM_011528294.2 RefSeq; XP_011526597.1; XM_011528295.2 RefSeq; XP_016882792.1; XM_017027303.1 RefSeq; XP_016882793.1; XM_017027304.1 RefSeq; XP_016882794.1; XM_017027305.1 UniGene; Hs.515111; - ProteinModelPortal; Q9HA82; - SMR; Q9HA82; - BioGrid; 122740; 2 IntAct; Q9HA82; 34 STRING; 9606.ENSP00000251363; - SwissLipids; SLP:000000699; - iPTMnet; Q9HA82; - PhosphoSitePlus; Q9HA82; - BioMuta; CERS4; - DMDM; 296434561; - EPD; Q9HA82; - MaxQB; Q9HA82; - PaxDb; Q9HA82; - PeptideAtlas; Q9HA82; - PRIDE; Q9HA82; - ProteomicsDB; 81384; - DNASU; 79603; - Ensembl; ENST00000251363; ENSP00000251363; ENSG00000090661 Ensembl; ENST00000559450; ENSP00000453509; ENSG00000090661 GeneID; 79603; - KEGG; hsa:79603; - UCSC; uc002mjg.4; human CTD; 79603; - DisGeNET; 79603; - EuPathDB; HostDB:ENSG00000090661.11; - GeneCards; CERS4; - HGNC; HGNC:23747; CERS4 HPA; CAB033734; - HPA; HPA054729; - MIM; 615334; gene neXtProt; NX_Q9HA82; - OpenTargets; ENSG00000090661; - PharmGKB; PA134915173; - eggNOG; KOG1607; Eukaryota eggNOG; COG5058; LUCA GeneTree; ENSGT00550000074401; - HOGENOM; HOG000231977; - HOVERGEN; HBG052310; - InParanoid; Q9HA82; - KO; K04710; - OMA; LYHESWL; - OrthoDB; EOG091G0BWM; - PhylomeDB; Q9HA82; - TreeFam; TF314319; - Reactome; R-HSA-1660661; Sphingolipid de novo biosynthesis GenomeRNAi; 79603; - PRO; PR:Q9HA82; - Proteomes; UP000005640; Chromosome 19 Bgee; ENSG00000090661; - CleanEx; HS_LASS4; - ExpressionAtlas; Q9HA82; baseline and differential Genevisible; Q9HA82; HS GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW GO; GO:0050291; F:sphingosine N-acyltransferase activity; IBA:GO_Central GO; GO:0046513; P:ceramide biosynthetic process; IBA:GO_Central GO; GO:0030148; P:sphingolipid biosynthetic process; TAS:Reactome CDD; cd00086; homeodomain; 1 InterPro; IPR009057; Homeobox-like_sf InterPro; IPR001356; Homeobox_dom InterPro; IPR016439; Lag1/Lac1-like InterPro; IPR006634; TLC-dom PANTHER; PTHR12560; PTHR12560; 1 Pfam; PF00046; Homeobox; 1 Pfam; PF03798; TRAM_LAG1_CLN8; 1 PIRSF; PIRSF005225; LAG1_LAC1; 1 SMART; SM00724; TLC; 1 SUPFAM; SSF46689; SSF46689; 1 PROSITE; PS50071; HOMEOBOX_2; 1 PROSITE; PS50922; TLC; 1 1: Evidence at protein level; Complete proteome; DNA-binding; Endoplasmic reticulum; Homeobox; Lipid biosynthesis; Lipid metabolism; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix CHAIN 1 394 Ceramide synthase 4 /FTId=PRO_0000185512 TRANSMEM 32 52 Helical. TRANSMEM 140 160 Helical. TRANSMEM 179 199 Helical. TRANSMEM 209 229 Helical. TRANSMEM 260 280 Helical. TRANSMEM 304 324 Helical. DOMAIN 131 332 TLC. {ECO:0000255|PROSITE- ProRule:PRU00205} DNA_BIND 67 128 Homeobox. {ECO:0000255|PROSITE- ProRule:PRU00108} MOD_RES 342 342 Phosphoserine {ECO:0000250|UniProtKB:Q9D6J1} MOD_RES 349 349 Phosphoserine {ECO:0000250|UniProtKB:Q9D6J1} MOD_RES 350 350 Phosphoserine {ECO:0000250|UniProtKB:Q9D6J1} VARIANT 119 119 R -> Q (in dbSNP:rs17159388) /FTId=VAR_034065 VARIANT 301 301 G -> S (in dbSNP:rs2288413) /FTId=VAR_019556 VARIANT 353 353 A -> V (in dbSNP:rs17160348) /FTId=VAR_060263 VARIANT 366 366 A -> T (in dbSNP:rs36259) {ECO:0000269|Ref.3} /FTId=VAR_019557 VARIANT 379 379 R -> Q (in dbSNP:rs17160349) /FTId=VAR_060264 SEQUENCE 394 AA; 46399 MW; DAA12AA386ED2802 CRC64; MLSSFNEWFW QDRFWLPPNV TWTELEDRDG RVYPHPQDLL AALPLALVLL AMRLAFERFI GLPLSRWLGV RDQTRRQVKP NATLEKHFLT EGHRPKEPQL SLLAAQCGLT LQQTQRWFRR RRNQDRPQLT KKFCEASWRF LFYLSSFVGG LSVLYHESWL WAPVMCWDRY PNQTLKPSLY WWYLLELGFY LSLLIRLPFD VKRKDFKEQV IHHFVAVILM TFSYSANLLR IGSLVLLLHD SSDYLLEACK MVNYMQYQQV CDALFLIFSF VFFYTRLVLF PTQILYTTYY ESISNRGPFF GYYFFNGLLM LLQLLHVFWS CLILRMLYSF MKKGQMEKDI RSDVEESDSS EEAAAAQEPL QLKNGAAGGP RPAPTDGPRS RVAGRLTNRH TTAT
Research Areas
Citations (0)

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Background

May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity).

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 80.00
Cat# BP21979a
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