|Other Names||Lethal(2) giant larvae protein homolog 1, LLGL, DLG4, Hugl-1, Human homolog to the D-lgl gene protein, LLGL1, DLG4, HUGL, HUGL1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2197b was selected from the C-term region of human LLGL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DLG4, HUGL, HUGL1|
|Function||Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.|
|Cellular Location||Early endosome membrane. Golgi apparatus, trans-Golgi network membrane. Golgi apparatus membrane. Cell projection, axon. Cytoplasm, cytoskeleton Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developping axons (By similarity).|
|Tissue Location||Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease|
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LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17.
Schimanski, C.C., et al., Oncogene 24(19):3100-3109 (2005).Grifoni, D., et al., Oncogene 23(53):8688-8694 (2004).Katoh, M., et al., Int. J. Oncol. 24(3):737-742 (2004).Bi, W., et al., Genome Res. 12(5):713-728 (2002).Ludford-Menting, M.J., et al., J. Biol. Chem. 277(6):4477-4484 (2002).
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