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LARGE Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession O95461
Other Accession Q66PG4, Q66PG1, Q8N3Y3, Q66PG3, Q66PG2, Q9Z1M7
Additional Information
Gene ID 9215
Other Names Glycosyltransferase-like protein LARGE1, 2.4.-.-, Acetylglucosaminyltransferase-like 1A, Xylosyltransferase LARGE, 2.4.2.-, Beta-1, 3-glucuronyltransferase LARGE, 2.4.1.-, LARGE, KIAA0609, LARGE1
Target/Specificity The synthetic peptide sequence is selected from aa 385-398 of HUMAN LARGE
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LARGE1 (HGNC:6511)
Synonyms KIAA0609, LARGE
Function Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine- beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:22223806). Phosphorylated O- mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:25279699).
Cellular Location Golgi apparatus membrane; Single-pass type II membrane protein
Tissue Location Ubiquitous. Highest expression in heart, brain and skeletal muscle.
Research Areas
Citations (0)

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Background

Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine- beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:22223806). Phosphorylated O- mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:25279699).

References

Peyrard M.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:598-603(1999).
Nagase T.,et al.DNA Res. 5:31-39(1998).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Dunham I.,et al.Nature 402:489-495(1999).
Fujimura K.,et al.Biochem. Biophys. Res. Commun. 329:1162-1171(2005).

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$ 80.00
Cat# BP21980c
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